Ontology highlight
ABSTRACT:
SUBMITTER: Senese S
PROVIDER: S-EPMC5732783 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Senese Silvia S Lo Yu-Chen YC Gholkar Ankur A AA Li Chien-Ming CM Huang Yong Y Mottahedeh Jack J Kornblum Harley I HI Damoiseaux Robert R Torres Jorge Z JZ
Oncotarget 20171019 61
Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effective chemotherapeutic agents that target the dynamic instability of microtubules and inhibit spindle functioning. However, these drugs have limitations associated with their production, solubility, efficacy and unwanted toxicities, thus driving the need to identify novel antimitotic drugs that can be used as anticancer agents. We have discovered and characterized the Microtubins (Microtubule inhib ...[more]