The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease.

ABSTRACT:

Objective

To assess the trajectory of perioperative brain growth in relationship to cardiac diagnosis and acquired brain injuries.

Methods

This was a cohort study of term neonates with hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (d-TGA). Subjects underwent magnetic resonance imaging of the brain pre- and postoperatively to determine the severity of brain injury and total and regional brain volumes by the use of automated morphometry. Comparisons were made by cardiac lesion and injury status.

Results

A total of 79 subjects were included (49, d-TGA; 30, HLHS). Subjects with HLHS had more postoperative brain injury (55.6% vs 30.4%, P = .03) and more severe brain injury (moderate-to-severe white matter [WM] injury, P = .01). Total and

SUBMITTER: Peyvandi S 

PROVIDER: S-EPMC5732841 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature