Ontology highlight
ABSTRACT:
SUBMITTER: Saba NS
PROVIDER: S-EPMC5732856 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Saba Nakhle S NS Wong Deanna H DH Tanios Georges G Iyer Jessica R JR Lobelle-Rich Patricia P Dadashian Eman L EL Liu Delong D Fontan Lorena L Flemington Erik K EK Nichols Cydney M CM Underbayev Chingiz C Safah Hana H Melnick Ari A Wiestner Adrian A Herman Sarah E M SEM
Cancer research 20171009 24
The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged by the frequent emergence of resistant clones. The ibrutinib target, Bruton's tyrosine kinase (BTK), is essential for B-cell receptor signaling, and most resistant cases carry mutations in <i>BTK</i> or <i>PLCG2</i>, a downstream effector target of BTK. Recent findings show that MI-2, a small molecule inhibitor of the para-caspase MALT1, is effective in preclinical models of another type of BCR ...[more]