Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC5733105 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in immunology 20171212
Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with HDAC1, which downregulated the acetylation level of NP. Using mass spectrometry, we identified lysine 103 as an acetylation site of the NP. Compared with wild-type protein, two K103 ...[more]