Ontology highlight
ABSTRACT:
SUBMITTER: Berthelot C
PROVIDER: S-EPMC5733139 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Berthelot Camille C Villar Diego D Horvath Julie E JE Odom Duncan T DT Flicek Paul P
Nature ecology & evolution 20171127 1
To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from 15 species. Genes associated with complex regulatory landscapes generally exhibit high expression levels that remain evolutionarily stable. While the number of regulatory elements is the key driver of transcriptional output and resilience, regulatory conservation matters: elements ac ...[more]