Ontology highlight
ABSTRACT:
SUBMITTER: Shadrick WR
PROVIDER: S-EPMC5733700 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Shadrick William R WR Slavish Peter J PJ Chai Sergio C SC Waddell Brett B Connelly Michele M Low Jonathan A JA Tallant Cynthia C Young Brandon M BM Bharatham Nagakumar N Knapp Stefan S Boyd Vincent A VA Morfouace Marie M Roussel Martine F MF Chen Taosheng T Lee Richard E RE Kiplin Guy R R Shelat Anang A AA Potter Philip M PM
Bioorganic & medicinal chemistry 20171104 1
Within the last decade, the Bromodomain and Extra-Terminal domain family (BET) of proteins have emerged as promising drug targets in diverse clinical indications including oncology, auto-immune disease, heart failure, and male contraception. The BET family consists of four isoforms (BRD2, BRD3, BRD4, and BRDT/BRDT6) which are distinguished by the presence of two tandem bromodomains (BD1 and BD2) that independently recognize acetylated-lysine (KAc) residues and appear to have distinct biological ...[more]