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Complications preceding early deaths in Black and White children with acute myeloid leukemia.


ABSTRACT: Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.

SUBMITTER: Winestone LE 

PROVIDER: S-EPMC5733774 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Complications preceding early deaths in Black and White children with acute myeloid leukemia.

Winestone Lena E LE   Getz Kelly D KD   Miller Tamara P TP   Li Yimei Y   Huang Yuan-Shung YS   Seif Alix E AE   Fisher Brian T BT   Aplenc Richard R  

Pediatric blood & cancer 20170720 12


Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in  ...[more]

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