Host Genetic Control of the Oral Microbiome in Health and Disease.
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ABSTRACT:
SUBMITTER: Gomez A
PROVIDER: S-EPMC5733791 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Host Genetic Control of the Oral Microbiome in Health and Disease.
Gomez Andres A Espinoza Josh L JL Harkins Derek M DM Leong Pamela P Saffery Richard R Bockmann Michelle M Torralba Manolito M Kuelbs Claire C Kodukula Rohith R Inman Jason J Hughes Toby T Craig Jeffrey M JM Highlander Sarah K SK Jones Marcus B MB Dupont Chris L CL Nelson Karen E KE
Cell host & microbe 20170901 3
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged 5-11. Oral microbiome similarity always increased with shared ...[more]
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