Ontology highlight
ABSTRACT:
SUBMITTER: Xia L
PROVIDER: S-EPMC5734604 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20171121 23
We report on the synthesis and biological evaluation of a series of 1,2-diarylimidazol-4-carboxamide derivatives developed as CB<sub>1</sub> receptor antagonists. These were evaluated in a radioligand displacement binding assay, a [<sup>35</sup>S]GTPγS binding assay, and in a competition association assay that enables the relatively fast kinetic screening of multiple compounds. The compounds show high affinities and a diverse range of kinetic profiles at the CB<sub>1</sub> receptor and their str ...[more]