Ontology highlight
ABSTRACT:
SUBMITTER: Bayliss T
PROVIDER: S-EPMC5734605 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20171122 23
N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness. We have previously validated T. brucei NMT as a promising druggable target for the treatment of HAT in both stages 1 and 2 of the disease. We report on the use of the previously reported DDD85646 (1) as a starting point for the design of a class of potent, brain penetrant inhibitors of T. br ...[more]