Ronin influences the DNA damage response in pluripotent stem cells.
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ABSTRACT:
SUBMITTER: Seifert BA
PROVIDER: S-EPMC5734626 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Ronin influences the DNA damage response in pluripotent stem cells.
Seifert Bryce A BA Dejosez Marion M Zwaka Thomas P TP
Stem cell research 20170703
Early mammalian embryonic cells must maintain a particularly robust DNA repair system, as mutations at this developmental point have detrimental consequences for the organism. How the repair system can be tuned to fulfill such elevated requirements is largely unknown, but it may involve transcriptional regulation. Ronin (Thap11) is a transcriptional regulator responsible for vital programs in pluripotent cells. Here, we report that this protein also modulates the DNA damage response of such cell ...[more]
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