Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC5735013 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yuan Xiaoyi X Lee Jae W JW Bowser Jessica L JL Neudecker Viola V Sridhar Srikanth S Eltzschig Holger K HK
Anesthesia and analgesia 20180101 1
Perioperative organ injury has a significant impact on surgical outcomes and presents a leading cause of death in the United States. Recent research has pointed out an important role of hypoxia signaling in the protection from organ injury, including for example myocardial infarction, acute respiratory distress syndrome, acute kidney, or gut injury. Hypoxia induces the stabilization of hypoxia-inducible factors (HIFs), thereby leading to the induction of HIF target genes, which facilitates adapt ...[more]