Ontology highlight
ABSTRACT:
SUBMITTER: Chi XZ
PROVIDER: S-EPMC5735299 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Chi X-Z XZ Lee J-W JW Lee Y-S YS Park I Y IY Ito Y Y Bae S-C SC
Oncogene 20170828 50
The restriction (R)-point decision is fundamental to normal differentiation and the G<sub>1</sub>-S transition, and the decision-making machinery is perturbed in nearly all cancer cells. The mechanisms underlying the cellular context-dependent R-point decision remain poorly understood. We found that the R-point was dysregulated in Runx3<sup>-/-</sup>mouse embryonic fibroblasts (MEFs), which formed tumors in nude mice. Ectopic expression of Runx3 restored the R-point and abolished the tumorigenic ...[more]