Ontology highlight
ABSTRACT:
SUBMITTER: Yunes-Medina L
PROVIDER: S-EPMC5736014 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yunes-Medina Laura L Paciorkowski Alex A Nuzbrokh Yan Y Johnson Gail V W GVW
Molecular and cellular neurosciences 20171129
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to examine the role of TG2 in neuronal survival and to begin to delineate the pathways it regulates. We show that depletion of TG2 significantly compromises the viability of neurons in the absence of any stressors. RNA sequencing revealed that depletion o ...[more]