Ontology highlight
ABSTRACT:
SUBMITTER: Landais E
PROVIDER: S-EPMC5736302 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Immunity 20171101 5
Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development of neutralization breadth. The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino acids, among the shortest known for this class of Abs, and achieved breadth with only 10% nuc ...[more]