Ontology highlight
ABSTRACT:
SUBMITTER: Majri SS
PROVIDER: S-EPMC5736408 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Majri Sonia S SS Fritz Jill M JM Villarino Alejandro V AV Zheng Lixin L Kanellopoulou Chrysi C Chaigne-Delalande Benjamin B Grönholm Juha J Niemela Julie E JE Afzali Behdad B Biancalana Matthew M Pittaluga Stefania S Sun Ashleigh A Cohen José L JL Holland Steven M SM O'Shea John J JJ Uzel Gulbu G Lenardo Michael J MJ
Journal of immunology (Baltimore, Md. : 1950) 20171129 1
Understanding the control of Ag restimulation-induced T cell death (RICD), especially in cancer immunotherapy, where highly proliferating T cells will encounter potentially large amounts of tumor Ags, is important now more than ever. It has been known that growth cytokines make T cells susceptible to RICD, but the precise molecular mediators that govern this in T cell subsets is unknown until now. STAT proteins are a family of transcription factors that regulate gene expression programs underlyi ...[more]