Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC5736752 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Liu David D Abbosh Philip P Keliher Daniel D Reardon Brendan B Miao Diana D Mouw Kent K Weiner-Taylor Amaro A Wankowicz Stephanie S Han Garam G Teo Min Yuen MY Cipolla Catharine C Kim Jaegil J Iyer Gopa G Al-Ahmadie Hikmat H Dulaimi Essel E Chen David Y T DYT Alpaugh R Katherine RK Hoffman-Censits Jean J Garraway Levi A LA Getz Gad G Carter Scott L SL Bellmunt Joaquim J Plimack Elizabeth R ER Rosenberg Jonathan E JE Van Allen Eliezer M EM
Nature communications 20171219 1
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matched pre- and post-neoadjuvant cisplatin-based chemotherapy primary bladder tumor samples from 30 muscle-invasive bladder cancer patients. We observe no overall increase in tumor mutational burden post-chemotherapy, though a significant proportion of subclonal mutations are unique to the match ...[more]