Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC5736846 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Jin Yan Y Regev Arie A Kam Jeanelle J Phipps Krista K Smith Claire C Henck Judith J Campanale Kristina K Hu Leijun L Hall D Greg DG Yang Xiao Yan XY Nakano Masako M McNearney Terry Ann TA Uetrecht Jack J Landschulz William W
British journal of clinical pharmacology 20171008 1
<h4>Aims</h4>LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies and a single ascending dose study demonstrated an acceptable toxicity, safety and tolerability profile.<h4>Methods</h4>Healthy subjects were randomized to receive LY3031207 (25, 75 and 275 mg), placebo or celecoxib (400 mg) once daily for 28 days. The safety, tolerability and pharmacokinetic and pharmacodynamic profiles of LY303120 ...[more]