Ontology highlight
ABSTRACT:
SUBMITTER: Richter MF
PROVIDER: S-EPMC5737020 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Richter Michelle F MF Drown Bryon S BS Riley Andrew P AP Garcia Alfredo A Shirai Tomohiro T Svec Riley L RL Hergenrother Paul J PJ
Nature 20170510 7654
Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, making the discovery of much-needed drugs against these pathogens challenging. Current understanding of the physicochemical properties that dictate small-molecule accumulation in Gram-negative bacteria is largely based on retrospective analyses of antibacterial agents, which suggest that polarity and molecular weight are key factors. Here we assess the ability of ov ...[more]