Ontology highlight
ABSTRACT:
SUBMITTER: Kwun J
PROVIDER: S-EPMC5737135 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Kwun Jean J Burghuber Christopher C Manook Miriam M Ezekian Brian B Park Jaeberm J Yoon Janghoon J Yi John S JS Iwakoshi Neal N Gibby Adriana A Hong Jung Joo JJ Farris Alton B AB Kirk Allan D AD Knechtle Stuart J SJ
Blood advances 20171026 24
The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound. Proteasome inhibitors (PIs) deplete antibody-producing plasma cells (PCs) but have shown marginal benefit for desensitization. In an allosensitized nonhuman primate (NHP) model, we observed increased germinal center (GC) formation after PI monotherapy, suggesting a compensatory PC repopula ...[more]