Ontology highlight
ABSTRACT:
SUBMITTER: Malfatti MC
PROVIDER: S-EPMC5737539 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Malfatti Matilde Clarissa MC Balachander Sathya S Antoniali Giulia G Koh Kyung Duk KD Saint-Pierre Christine C Gasparutto Didier D Chon Hyongi H Crouch Robert J RJ Storici Francesca F Tell Gianluca G
Nucleic acids research 20171101 19
Ribonucleoside 5'-monophosphates (rNMPs) are the most common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs transiently incorporated in the mammalian genome per cell cycle. Human ribonuclease (RNase) H2 is the principal enzyme able to cleave rNMPs in DNA. Whether RNase H2 may process abasic or oxidized rNMPs incorporated in DNA is unknown. The base excision repair (BER) pathway is mainly responsible for repairing oxidized and abasic sites into DNA. Here we ...[more]