Ontology highlight
ABSTRACT:
SUBMITTER: Wang XT
PROVIDER: S-EPMC5737579 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wang Xiao-Tao XT Cui Wang W Peng Cheng C
Nucleic acids research 20171101 19
A current question in the high-order organization of chromatin is whether topologically associating domains (TADs) are distinct from other hierarchical chromatin domains. However, due to the unclear TAD definition in tradition, the structural and functional uniqueness of TAD is not well studied. In this work, we refined TAD definition by further constraining TADs to the optimal separation on global intra-chromosomal interactions. Inspired by this constraint, we developed a novel method, called H ...[more]