Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5737673 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Wang Steven S Pike Alexandra M AM Lee Stella S SS Strong Margaret A MA Connelly Carla J CJ Greider Carol W CW
Nucleic acids research 20170801 14
Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which trigger the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as a therapeutic target. Using an unbiased shRNA screen targeting known kinases, we identified bromodomain-containing protein 4 (BRD4) as a telomere length regulator. Four independent BRD4 inhibitors blocked telomere elongation, in a dose-dependent manner, ...[more]