Ontology highlight
ABSTRACT:
SUBMITTER: Bell JM
PROVIDER: S-EPMC5737808 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Bell John M JM Lau Billy T BT Greer Stephanie U SU Wood-Bouwens Christina C Xia Li C LC Connolly Ian D ID Gephart Melanie H MH Ji Hanlee P HP
Nucleic acids research 20171101 19
Genomic instability is a frequently occurring feature of cancer that involves large-scale structural alterations. These somatic changes in chromosome structure include duplication of entire chromosome arms and aneuploidy where chromosomes are duplicated beyond normal diploid content. However, the accurate determination of aneuploidy events in cancer genomes is a challenge. Recent advances in sequencing technology allow the characterization of haplotypes that extend megabases along the human geno ...[more]