Ventilator-associated respiratory infection in a resource-restricted setting: impact and etiology.

ABSTRACT: Background:Ventilator-associated respiratory infection (VARI) is a significant problem in resource-restricted intensive care units (ICUs), but differences in casemix and etiology means VARI in resource-restricted ICUs may be different from that found in resource-rich units. Data from these settings are vital to plan preventative interventions and assess their cost-effectiveness, but few are available. Methods:We conducted a prospective observational study in four Vietnamese ICUs to assess the incidence and impact of VARI. Patients ??16 years old and expected to be mechanically ventilated >?48 h were enrolled in the study and followed daily for 28 days following ICU admission. Results:Four hundred fifty eligible patients were enrolled over 24 months, and after exclusions, 374 patients' data were analyzed. A total of 92/374 cases of VARI (21.7/1000 ventilator days) were diagnosed; 37 (9.9%) of these met ventilator-associated pneumonia (VAP) criteria (8.7/1000 ventilator days). Patients with any VARI, VAP, or VARI without VAP experienced increased hospital and ICU stay, ICU cost, and antibiotic use (p?

SUBMITTER: Phu VD 

PROVIDER: S-EPMC5738227 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature