Major anomalies and birth-weight influence NICU interventions and mortality in infants with trisomy 13 or 18.

ABSTRACT: OBJECTIVE:To describe neonatal intensive care unit (NICU) medical interventions and NICU mortality by birth weight and major anomaly types for infants with trisomy 13 (T13) or 18 (T18). STUDY DESIGN:Retrospective cohort analysis of infants with T13 or T18 from 2005 to 2012 in the Pediatrix Medical Group. We classified infants into three groups by associated anomaly type: neonatal surgical, non-neonatal surgical and minor. Outcomes were NICU medical interventions and mortality. RESULTS:841 infants were included from 186 NICUs. NICU mortality varied widely by anomaly type and birth weight, from 70% of infants <1500?g with neonatal surgical anomalies to 31% of infants ?2500?g with minor anomalies. Infants ?1500?g without a neonatal surgical anomaly comprised 66% of infants admitted to the NICU; they had the lowest rates of NICU medical interventions and NICU mortality. CONCLUSIONS:Risk stratification by anomaly type and birth weight may help provide more accurate family counseling for infants with T13 and T18.

SUBMITTER: Acharya K 

PROVIDER: S-EPMC5738241 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature