Ontology highlight
ABSTRACT:
SUBMITTER: Riquelme SA
PROVIDER: S-EPMC5738266 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Riquelme Sebastián A SA Hopkins Benjamin D BD Wolfe Andrew L AL DiMango Emily E Kitur Kipyegon K Parsons Ramon R Prince Alice A
Immunity 20171212 6
The tumor suppressor PTEN controls cell proliferation by regulating phosphatidylinositol-3-kinase (PI3K) activity, but the participation of PTEN in host defense against bacterial infection is less well understood. Anti-inflammatory PI3K-Akt signaling is suppressed in patients with cystic fibrosis (CF), a disease characterized by hyper-inflammatory responses to airway infection. We found that Ptenl<sup>-/-</sup> mice, which lack the NH<sub>2</sub>-amino terminal splice variant of PTEN, were unabl ...[more]