Ontology highlight
ABSTRACT:
SUBMITTER: Dehghan E
PROVIDER: S-EPMC5738364 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Dehghan Esmaeil E Zhang Yiqiang Y Saremi Bahar B Yadavali Sivaramakrishna S Hakimi Amirmansoor A Dehghani Maryam M Goodarzi Mohammad M Tu Xiaoqin X Robertson Scott S Lin Rueyling R Chudhuri Asish A Mirzaei Hamid H
Nature communications 20171220 1
Nuclear factor (erythroid-derived 2)-like 2 and its Caenorhabditis elegans ortholog, SKN-1, are transcription factors that have a pivotal role in the oxidative stress response, cellular homeostasis, and organismal lifespan. Similar to other defense systems, the NRF2-mediated stress response is compromised in aging and neurodegenerative diseases. Here, we report that the FDA approved drug hydralazine is a bona fide activator of the NRF2/SKN-1 signaling pathway. We demonstrate that hydralazine ext ...[more]