Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia.

ABSTRACT:

Background

Schizophrenia is a chronic debilitating disease. The pathogenesis and treatment may be associated with inflammatory cytokines. There are few studies focusing on the prediction of cytokines in response to antipsychotics.

Aim

To investigate whether cytokines would predict response to antipsychotics.

Methods

Cross-sectional and natural observational cohort studies were applied to:(1) compare the baseline levels of serum IL-1β, TNF-α and MCP-1 between schizophrenia (n=64) and healthy controls (n=53); (2) To investigate the impact of baseline cytokines to psychopathology following olanzapine and risperidone monotherapy.

Results

(1) Baseline MCP-1 level of patients with schizophrenia was significantly higher than healthy controls (t=2.62, p=0.010),

SUBMITTER: Lin Y 

PROVIDER: S-EPMC5738517 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature