Ontology highlight
ABSTRACT:
SUBMITTER: Hamdy AK
PROVIDER: S-EPMC5738580 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hamdy Ahmed K AK Sheha Mahmoud M MM Abdel-Hafez Atef A AA Shouman Samia A SA
International journal of medicinal chemistry 20171207
Griseofulvin <b>1</b> is an important antifungal agent that has recently received attention due to its antiproliferative activity in mammalian cancer cells. Study of SAR of some griseofulvin analogues has led to the identification of 2'-benzyloxy griseofulvin <b>3</b>, a more potent analogue which retards tumor growth through inhibition of centrosomal clustering. However, similar to griseofulvin <b>1</b>, compound <b>3</b> exhibited poor aqueous solubility. In order to improve the poor water sol ...[more]