Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC5738625 | biostudies-literature | 2017 Oct-Dec
REPOSITORIES: biostudies-literature
Yu Lixia L Zhang Xiaoai X Zhai Yun Y Zhang Hongxing H Yue Wei W Zhang Xiumei X Wang Zhifu Z Zhou Hong H Zhou Gangqiao G Gong Feng F
Genetics and molecular biology 20171002 4
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors. In this study, we investigated whether SNPs in HPSE were a risk factor for hepatocellular carcinoma (HCC) by undertaking a comprehensive haplotype-tagging, case-control study. For this, six haplotype-tagging SNPs (htSNPs) in HPSE were genotyped in 400 HCC patients and 480 controls by polymerase chain reac ...[more]