Gene expression profiling in the developing rat brain exposed to ketamine.
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ABSTRACT:
SUBMITTER: Shi Q
PROVIDER: S-EPMC5739315 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Gene expression profiling in the developing rat brain exposed to ketamine.
Shi Q Q Guo L L Patterson T A TA Dial S S Li Q Q Sadovova N N Zhang X X Hanig J P JP Paule M G MG Slikker W W Wang C C
Neuroscience 20100118 3
Ketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, is associated with accelerated neuronal apoptosis in the developing rodent brain. In this study, postnatal day (PND) 7 rats were treated with 20 mg/kg ketamine or saline in six successive doses (s.c.) at 2-h intervals. Brain frontal cortical areas were collected 6 h after the last dose and RNA isolated and hybridized to Illumina Rat Ref-12 Expression BeadChips containing 22,226 probes. Many of the differentially express ...[more]
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