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Engineering Cell Surface Function with DNA Origami.

ABSTRACT: A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.

SUBMITTER: Akbari E

PROVIDER: S-EPMC5739518 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Engineering Cell Surface Function with DNA Origami.

Akbari Ehsan E Mollica Molly Y MY Lucas Christopher R CR Bushman Sarah M SM Patton Randy A RA Shahhosseini Melika M Song Jonathan W JW Castro Carlos E CE

Advanced materials (Deerfield Beach, Fla.) 20171013 46

A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipate ...[more]

PMID: 29027713

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