Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5739538 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhang Xiaodong X Saarinen Alicia M AM Hitosugi Taro T Wang Zhenghe Z Wang Liguo L Ho Thai H TH Liu Jun J
eLife 20171219
Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular lipolysis. Proteomics and functional analyses identified hypoxia-inducible gen ...[more]