Ontology highlight
ABSTRACT:
SUBMITTER: Woods EC
PROVIDER: S-EPMC5739539 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Woods Elliot C EC Kai FuiBoon F Barnes J Matthew JM Pedram Kayvon K Pickup Michael W MW Hollander Michael J MJ Weaver Valerie M VM Bertozzi Carolyn R CR
eLife 20171221
Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remains poorly understood. Here we report that a bulky glycocalyx promotes the expansion of disseminated tumor cells in vivo by fostering integrin adhesion assembly to permit G1 cell cycle progression. We engineered tumor cells to displa ...[more]