Ontology highlight
ABSTRACT:
SUBMITTER: Lohmueller JJ
PROVIDER: S-EPMC5739565 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lohmueller Jason J JJ Ham James D JD Kvorjak Michael M Finn Olivera J OJ
Oncoimmunology 20171026 1
Chimeric antigen receptor T cells (CAR-Ts) are promising cancer therapeutics. However, since cancer cells can lose the CAR-targeted antigen and avoid destruction, targeting multiple antigens with multiple CARs has been proposed. We illustrate here a less cumbersome alternative, anti-tag CARs (AT-CARs) that bind to tags on tumor-targeting antibodies. We have created novel AT-CARs, using the affinity-enhanced monomeric streptavidin 2 (mSA2) biotin-binding domain that when expressed on T cells can ...[more]