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MiR-20a-5p promotes radio-resistance by targeting NPAS2 in nasopharyngeal cancer cells.

ABSTRACT: MicroRNAs (miRNAs) are key players of gene expression involved in diverse biological processes including the cancer radio-resistance, which hinders the effective cancer therapy. Here we found that the miR-20a-5p level is significantly up-regulated in radio-resistant nasopharyngeal cancer (NPC) cells via an RNA-seq and miR-omic analysis. Moreover, we identified that the neuronal PAS domain protein 2 (NPAS2) gene is one of the targets of miR-20a-5p. The involvement of miR-20a-5p and NPAS2 with NPC radio-resistance was further validated by either down- or up-regulation of their levels in NPC cell lines. Taken together, these results not only reveal novel insights into the NPC radio-resistance, but also provide hints for an effective therapeutic strategy to fight against NPC radio-resistance.

SUBMITTER: Zhao F

PROVIDER: S-EPMC5739686 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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MiR-20a-5p promotes radio-resistance by targeting NPAS2 in nasopharyngeal cancer cells.

Zhao Fangfang F Pu Youguang Y Qian Liting L Zang Chunbao C Tao Zhenchao Z Gao Jin J

Oncotarget 20171111 62

MicroRNAs (miRNAs) are key players of gene expression involved in diverse biological processes including the cancer radio-resistance, which hinders the effective cancer therapy. Here we found that the miR-20a-5p level is significantly up-regulated in radio-resistant nasopharyngeal cancer (NPC) cells via an RNA-seq and miR-omic analysis. Moreover, we identified that the neuronal PAS domain protein 2 (NPAS2) gene is one of the targets of miR-20a-5p. The involvement of miR-20a-5p and NPAS2 with NPC ...[more]

PMID: 29285299

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