Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi T
PROVIDER: S-EPMC5739961 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Takahashi T T Hsiao H M HM Tanaka S S Li W W Higashikubo R R Scozzi D D Bharat A A Ritter J H JH Krupnick A S AS Gelman A E AE Kreisel D D
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20170823 1
Immunological requirements for rejection and tolerance induction differ between various organs. While memory CD8<sup>+</sup> T cells are considered a barrier to immunosuppression-mediated acceptance of most tissues and organs, tolerance induction after lung transplantation is critically dependent on central memory CD8<sup>+</sup> T lymphocytes. Here we demonstrate that costimulation blockade-mediated tolerance after lung transplantation is dependent on programmed cell death 1 (PD-1) expression o ...[more]