Ontology highlight
ABSTRACT:
SUBMITTER: Feng H
PROVIDER: S-EPMC5740130 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Feng Han H Liu Xuehui X Wang Sheng S Fleming Joy J Wang Da-Cheng DC Liu Wei W
Nature communications 20171221 1
New Delhi metallo-β-lactamases (NDMs), the recent additions to metallo-β-lactamases (MBLs), pose a serious public health threat due to its highly efficient hydrolysis of β-lactam antibiotics and rapid worldwide dissemination. The MBL-hydrolyzing mechanism for carbapenems is less studied than that of penicillins and cephalosporins. Here, we report crystal structures of NDM-1 in complex with hydrolyzed imipenem and meropenem, at resolutions of 1.80-2.32 Å, together with NMR spectra monitoring mero ...[more]