Ontology highlight
ABSTRACT:
SUBMITTER: Dornier E
PROVIDER: S-EPMC5740148 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Dornier Emmanuel E Rabas Nicolas N Mitchell Louise L Novo David D Dhayade Sandeep S Marco Sergi S Mackay Gillian G Sumpton David D Pallares Maria M Nixon Colin C Blyth Karen K Macpherson Iain R IR Rainero Elena E Norman Jim C JC
Nature communications 20171221 1
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not secrete glutamate. Indeed, low levels of extracellular glutamate are necessary to maintain epithelial homoeostasis, and provision of glutamate drives disruption of epithelial morphology and promotes key characteristics of the invas ...[more]