Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits.
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ABSTRACT:
SUBMITTER: Perrotta G
PROVIDER: S-EPMC5740253 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits.
Perrotta Gaetano G Bonnier Guillaume G Meskaldji Djalel-Eddine DE Romascano David D Aydarkhanov Ruslan R Daducci Alessandro A Simioni Samanta S Cavassini Matthias M Metral Melanie M Lazeyras François F Meuli Reto R Krueger Gunnar G Du Pasquier Renaud A RA Granziera Cristina C
Annals of clinical and translational neurology 20171107 12
Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neurocognitive disorders enrolled on a crossed over randomized rivastigmine trial. Rivastigmine therapy was as ...[more]
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