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In Vitro Activity of Meropenem-Vaborbactam against Clinical Isolates of KPC-Positive Enterobacteriaceae.


ABSTRACT: Vaborbactam (formerly RPX7009) is a novel inhibitor of serine ?-lactamases, including Ambler class A carbapenemases, such as KPCs. The current study evaluated the in vitro activity of the combination agent meropenem-vaborbactam against a global collection of 991 isolates of KPC-positive Enterobacteriaceae collected in 2014 and 2015 using the Clinical and Laboratory Standards Institute (CLSI) standard broth microdilution method. The MIC90 of meropenem (when tested with a fixed concentration of 8 ?g/ml of vaborbactam) for isolates of KPC-positive Enterobacteriaceae was 1 ?g/ml, and MIC values ranged from ?0.03 to >32 ?g/ml; 99.0% (981/991) of isolates had meropenem-vaborbactam MICs of ?4 ?g/ml, the U.S. FDA-approved MIC breakpoint for susceptibility to meropenem-vaborbactam (Vabomere). Vaborbactam lowered the meropenem MIC50 from 32 to 0.06 ?g/ml and the MIC90 from >32 to 1 ?g/ml. There were no differences in the activity of meropenem-vaborbactam when the isolates were stratified by KPC variant type. We conclude that meropenem-vaborbactam demonstrates potent in vitro activity against a worldwide collection of clinical isolates of KPC-positive Enterobacteriaceae collected in 2014 and 2015.

SUBMITTER: Hackel MA 

PROVIDER: S-EPMC5740317 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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<i>In Vitro</i> Activity of Meropenem-Vaborbactam against Clinical Isolates of KPC-Positive Enterobacteriaceae.

Hackel Meredith A MA   Lomovskaya Olga O   Dudley Michael N MN   Karlowsky James A JA   Sahm Daniel F DF  

Antimicrobial agents and chemotherapy 20171221 1


Vaborbactam (formerly RPX7009) is a novel inhibitor of serine β-lactamases, including Ambler class A carbapenemases, such as KPCs. The current study evaluated the <i>in vitro</i> activity of the combination agent meropenem-vaborbactam against a global collection of 991 isolates of KPC-positive <i>Enterobacteriaceae</i> collected in 2014 and 2015 using the Clinical and Laboratory Standards Institute (CLSI) standard broth microdilution method. The MIC<sub>90</sub> of meropenem (when tested with a  ...[more]

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