Ontology highlight
ABSTRACT:
SUBMITTER: Hackel MA
PROVIDER: S-EPMC5740317 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Hackel Meredith A MA Lomovskaya Olga O Dudley Michael N MN Karlowsky James A JA Sahm Daniel F DF
Antimicrobial agents and chemotherapy 20171221 1
Vaborbactam (formerly RPX7009) is a novel inhibitor of serine β-lactamases, including Ambler class A carbapenemases, such as KPCs. The current study evaluated the <i>in vitro</i> activity of the combination agent meropenem-vaborbactam against a global collection of 991 isolates of KPC-positive <i>Enterobacteriaceae</i> collected in 2014 and 2015 using the Clinical and Laboratory Standards Institute (CLSI) standard broth microdilution method. The MIC<sub>90</sub> of meropenem (when tested with a ...[more]