Ontology highlight
ABSTRACT:
SUBMITTER: Damodaren N
PROVIDER: S-EPMC5740667 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Damodaren Nivedita N Van Eeuwen Trevor T Zamel Joanna J Lin-Shiao Enrique E Kalisman Nir N Murakami Kenji K
Proceedings of the National Academy of Sciences of the United States of America 20171127 50
The DNA damage response is an essential process for the survival of living cells. In a subset of stress-responsive genes in humans, Elongin controls transcription in response to multiple stimuli, such as DNA damage, oxidative stress, and heat shock. Yeast Elongin (Ela1-Elc1), along with Def1, is known to facilitate ubiquitylation and degradation of RNA polymerase II (pol II) in response to multiple stimuli, yet transcription activity has not been examined. We have found that Def1 copurifies from ...[more]