The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis.

ABSTRACT:

Background

Intra-articular hyaluronic acid (IA-HA) is a common therapy used to treat knee pain and suppress knee inflammation in knee osteoarthritis (OA), typically prescribed in regimens ranging from a single injection to 5 weekly injections given once weekly. We conducted a systematic review to determine the efficacy of IA-HA, with subgroup analyses to explore the differences in knee pain and adverse events (AEs) across different dosing regimens.

Methods

We conducted a systematic search of the literature to identify studies evaluating IA-HA for the management of knee OA compared to IA-saline. Primary outcome measure was the mean knee pain score at 13 Weeks (3 months) or 26 weeks (6 months). Secondary outcome was the number of treatment-related AEs and treatment-related ser

SUBMITTER: Concoff A 

PROVIDER: S-EPMC5740709 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature