Genetic variation in human drug-related genes.
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ABSTRACT:
SUBMITTER: Scharfe CPI
PROVIDER: S-EPMC5740940 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic variation in human drug-related genes.
Schärfe Charlotta Pauline Irmgard CPI Tremmel Roman R Schwab Matthias M Kohlbacher Oliver O Marks Debora Susan DS
Genome medicine 20171222 1
<h4>Background</h4>Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.<h4>Methods</h4>Based on 60,706 human exomes from the ExAC dataset, we performed an in-depth computational analysis of the prevalence of functional variants in 806 drug-related genes, including 628 known drug targets. We furt ...[more]
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