Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5741087 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics.
Zhang Yong Y Sun Jie J Li Feng F Grogan Tristan R TR Vergara Jose L JL Luan QingXian Q Park Moon-Soo MS Chia David D Elashoff David D Joshipura Kaumudi J KJ Wong David T W DTW
Diabetes research and clinical practice 20170719
<h4>Aims</h4>Insulin resistance (IR) detection is challenging and no test is currently used in clinical practice. We developed salivary biomarkers that could be used for IR detection.<h4>Methods</h4>We collected saliva from 186 healthy and 276 pre-diabetic participants, divided them into high and low IR groups based on a HOMA cutoff of 2.5. We profiled extracellular transcriptome by microarray in saliva supernatant from 23 high IR and 15 low IR participants, and pre-validated the top ten extrace ...[more]
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