Ontology highlight
ABSTRACT:
SUBMITTER: Dey S
PROVIDER: S-EPMC5741093 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
ChemMedChem 20170831 18
Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target cells to cause infectious diseases in humans. The rise of drug resistance among pathogens that rely on the T3SS for infectivity, plus the dearth of new antibiotics require alternative strategies in developing new antibiotics. The Shigella T3SS tip protein IpaD is an attractive target for developing anti-infectives because of its essential ro ...[more]