Ontology highlight
ABSTRACT:
SUBMITTER: Matos-Cruz V
PROVIDER: S-EPMC5741102 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Matos-Cruz Vanessa V Schneider Eve R ER Mastrotto Marco M Merriman Dana K DK Bagriantsev Sviatoslav N SN Gracheva Elena O EO
Cell reports 20171201 12
Thirteen-lined ground squirrels and Syrian hamsters are known for their ability to withstand cold during hibernation. We found that hibernators exhibit cold tolerance even in the active state. Imaging and electrophysiology of squirrel somatosensory neurons reveal a decrease in cold sensitivity of TRPM8-expressing cells. Characterization of squirrel and hamster TRPM8 showed that the channels are chemically activated but exhibit poor activation by cold. Cold sensitivity can be re-introduced into s ...[more]