Unknown

Dataset Information

0

The Next Frontier: Head and Neck Cancer Immunoprevention.

ABSTRACT: Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. New experimental studies suggest that immune therapies can be used for HNSCC prevention rather than therapy. Given the current excitement for precision medicine, these findings support the future development of multimodality approaches for preventive immune oncology. Cancer Prev Res; 10(12); 681-3. ©2017 AACRSee related article by Jin Wang, et al., p. 684.

SUBMITTER: Gutkind JS 

PROVIDER: S-EPMC5741293 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The Next Frontier: Head and Neck Cancer Immunoprevention.

Gutkind J Silvio JS   Bui Jack D JD  

Cancer prevention research (Philadelphia, Pa.) 20171114 12

Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. New experimental studies suggest th  ...[more]

Similar Datasets

Unknown Cancer immunoprevention--the next frontier.
| S-EPMC4361891 | biostudies-literature
Unknown Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.
| S-EPMC8122210 | biostudies-literature
Unknown Oral Microbiota-A New Frontier in the Pathogenesis and Management of Head and Neck Cancers.
| S-EPMC8750462 | biostudies-literature
Unknown Cancer Immunoprevention and Public Health.
| S-EPMC5421153 | biostudies-literature
Unknown Head and neck cancer: an overview.
| S-EPMC3324241 | biostudies-other
Unknown Cone beam navigation bronchoscopy: the next frontier.
| S-EPMC7330771 | biostudies-literature
Unknown MicroRNAs in Head and Neck Cancer.
| S-EPMC3821954 | biostudies-literature
Unknown Head and neck cancer: metronomic chemotherapy.
| S-EPMC4603691 | biostudies-literature
Unknown HPV Associated Head and Neck Cancer.
| S-EPMC4999784 | biostudies-literature
Genomics Head and neck cancer neural reprogramming
2020-02-13 | GSE140324 | GEO