Ontology highlight
ABSTRACT:
SUBMITTER: Alves-Paiva RM
PROVIDER: S-EPMC5741503 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Alves-Paiva Raquel M RM Kajigaya Sachiko S Feng Xingmin X Chen Jichun J Desierto Marie M Wong Susan S Townsley Danielle M DM Donaires Flávia S FS Bertola Adeline A Gao Bin B Young Neal S NS Calado Rodrigo T RT
Liver international : official journal of the International Association for the Study of the Liver 20170819 1
<h4>Background & aims</h4>Short telomeres and genetic telomerase defects are risk factors for some human liver diseases, ranging from non-alcoholic fatty liver disease and non-alcoholic steatohepatitis to cirrhosis. In murine models, telomere dysfunction has been shown to metabolically compromise hematopoietic cells, liver and heart via the activation of the p53-PGC axis.<h4>Methods</h4>Tert- and Terc-deficient mice were challenged with liquid high-fat diet. Liver metabolic contents were analyse ...[more]